Body Composition in Late Midlife as a Predictor of Accelerated Age-associated Deficit-accumulation From Late Midlife into Old Age : A Longitudinal Birth Cohort Study
Publiceringsår
2023
Upphovspersoner
Haapanen, Markus J.; Mikkola, Tuija M.; Kortelainen, Lauri; Jylhävä, Juulia; Wasenius, Niko S.; Kajantie, Eero; Eriksson, Johan G.; von Bonsdorff, Mikaela B.
Abstrakt
Background Body mass index (BMI) may not be an optimal predictor of frailty as its constituents, lean and fat mass, may have opposite associations with frailty. Methods A linear mixed model analysis was performed in the Helsinki Birth Cohort Study (n=2000) spanning from 57 to 84 years. A 39-item frailty index (FI) was calculated on three occasions over 17 years. Body composition in late midlife included BMI, percent body fat (%BF), waist-to-hip ratio (WHR), lean mass index (LMI), and fat mass index (FMI). Results Mean FI levels increased by 0.28%/year among men and by 0.34%/year among women. Among women, per each kg/m 2 higher BMI and each unit higher %BF the increases in FI levels per year were 0.013 percentage points (PP) steeper (95% CI=0.004, 0.023) and 0.009 PP steeper (95% CI=0.002, 0.016) from late midlife into old age. Among men, per each 0.1-unit greater WHR the increase in FI levels was 0.074 PP steeper per year (95% CI=-0.0004, 0.148). Cross-sectionally, greater FMI and LMI in late midlife were associated with higher FI levels but the direction of the association regarding LMI changed after adjustment for FMI. The categories ‘high FMI & high LMI’ and ‘high FMI & low LMI’ showed the highest FI levels relative to the category ‘low FMI & low LMI’. Conclusions In late midlife, greater adiposity (%BF) among women and abdominal obesity (WHR) among men may predispose to higher levels of frailty from late midlife into old age. Greater lean mass alone may be protective of frailty, but not in the presence of high fat mass.
Visa merOrganisationer och upphovspersoner
Uleåborgs universitet
Kajantie Eero
Östra Finlands universitet
Kortelainen Lauri Jalmari
Institutet för hälsa och välfärd
Kajantie Eero
Helsingforsregionens universitetscentralsjukhus specialupptagningsområde
Kajantie Eero
Eriksson Johan G.
Wasenius Niko S.
Mikkola Tuija M.
Publikationstyp
Publikationsform
Artikel
Moderpublikationens typ
Tidning
Artikelstyp
En originalartikel
Målgrupp
VetenskapligKollegialt utvärderad
Kollegialt utvärderadUKM:s publikationstyp
A1 Originalartikel i en vetenskaplig tidskriftPublikationskanalens uppgifter
Moderpublikationens namn
Journals of Gerontology. Series A: Biological Sciences and Medical Sciences
Volym
78
Nummer
6
Sidor
980–987
ISSN
Publikationsforum
Publikationsforumsnivå
3
Öppen tillgång
Öppen tillgänglighet i förläggarens tjänst
Ja
Öppen tillgång till publikationskanalen
Delvis öppen publikationskanal
Licens för förläggarens version
CC BY
Parallellsparad
Ja
Övriga uppgifter
Vetenskapsområden
Allmänmedicin, inre medicin och annan klinisk medicin; Hälsovetenskap; Folkhälsovetenskap, miljö och arbetshälsa
Nyckelord
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Publiceringsland
Förenta staterna (USA)
Förlagets internationalitet
Internationell
Språk
engelska
Internationell sampublikation
Ja
Sampublikation med ett företag
Nej
DOI
10.1093/gerona/glac233
Publikationen ingår i undervisnings- och kulturministeriets datainsamling
Ja