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Accelerated size-focusing light activated synthesis of atomically precise fluorescent Au22(Lys–Cys–Lys)16 clusters

Publiceringsår

2024

Upphovspersoner

Aminfar, Parimah; Ferguson, Travis; Steele, Emily; MacNeil, Emerson M.; Matus, María Francisca; Malola, Sami; Häkkinen, Hannu; Duchesne, Paul N.; Loock, Hans-Peter; Stamplecoskie, Kevin G.

Abstrakt

Atomically precise metal nanoclusters are promising candidates for various biomedical applications, including their use as photosensitizers in photodynamic therapy (PDT). However, typical synthetic routes of clusters often result in complex mixtures, where isolating and characterizing pure samples becomes challenging. In this work, a new Au22(Lys–Cys–Lys)16 cluster is synthesized using photochemistry, followed by a new type of light activated, accelerated size-focusing. Fluorescence excitation–emission matrix spectroscopy (EEM) and parallel factor (PARAFAC) analysis have been applied to track the formation of fluorescent species, and to assess optical purity of the final product. Furthermore, excited state reactivity of Au22(Lys–Cys–Lys)16 clusters is studied, and formation of type-I reactive oxygen species (ROS) from the excited state of the clusters is observed. The proposed size-focusing procedure in this work can be easily adapted to conventional cluster synthetic methods, such as borohydride reduction, to provide atomically precise clusters.
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Organisationer och upphovspersoner

Jyväskylä universitet

Häkkinen Hannu

Matus Cortés Maria Orcid -palvelun logo

Malola Sami

Publikationstyp

Publikationsform

Artikel

Moderpublikationens typ

Tidning

Artikelstyp

En originalartikel

Målgrupp

Vetenskaplig

Kollegialt utvärderad

Kollegialt utvärderad

UKM:s publikationstyp

A1 Originalartikel i en vetenskaplig tidskrift

Publikationskanalens uppgifter

Volym

16

Nummer

1

Sidor

205-211

Publikationsforum

63714

Publikationsforumsnivå

3

Öppen tillgång

Öppen tillgänglighet i förläggarens tjänst

Nej

Parallellsparad

Ja

Övriga uppgifter

Vetenskapsområden

Fysik; Nanoteknologi

Nyckelord

[object Object],[object Object]

Publiceringsland

Förenade kungariket

Förlagets internationalitet

Internationell

Språk

engelska

Internationell sampublikation

Ja

Sampublikation med ett företag

Nej

DOI

10.1039/d3nr04793h

Publikationen ingår i undervisnings- och kulturministeriets datainsamling

Ja