Broad-spectrum antivirals from nature : studies on efficacy and molecular mechanism
Publiceringsår
2023
Upphovspersoner
Reshamwala, Dhanik
Abstrakt
Viral diseases and their outbreaks continue to challenge our society. They are not only responsible for causing numerous infections but also disrupt the global economy and public health system. The recent COVID-19 pandemic was one of the most catastrophic event in human history that caused millions of fatalities worldwide. Enteroviruses are group of viruses that cause an array of diseases ranging from the mild, common cold to more severe infections like myocarditis and central nervous system infections. They are also associated with chronic infections such as type I diabetes. Currently, no antivirals have been clinically approved against enteroviruses and only one drug has been granted a conditional marketing authorization against coronaviruses by the European medicines agency (EMA). It has become important that one looks beyond the conventional routes and explore bioactive compounds from natural products to identify novel broad-spectrum antivirals. This study concentrates on the screening of different natural compounds for their antiviral potential against enteroviruses and coronaviruses and investigates their mechanism of action. We found broad-spectrum antiviral activity of Salix bark extract and Ganoderma sp. ferment against enveloped and non-enveloped viruses. These natural antivirals inhibited enteroviruses by stabilizing them and preventing their genome release. In contrast, the bark extract treatment led to disruption of coronaviruses. In addition, polyphenolic compounds also exhibited potent antiviral efficacy against enteroviruses and their efficacy was improved by several folds when they were functionalized on the surface of nanoparticles. Polyphenols inhibited the infection by binding at multiple sites on the virus capsid, leading to clustering and stabilization of the virus.
Visa merOrganisationer och upphovspersoner
Jyväskylä universitet
Reshamwala Dhanik
Publikationstyp
Publikationsform
Separat verk
Målgrupp
Vetenskaplig
UKM:s publikationstyp
G5 Artikelavhandling
Publikationskanalens uppgifter
Öppen tillgång
Öppen tillgänglighet i förläggarens tjänst
Ja
Öppen tillgång till publikationskanalen
Helt öppen publikationskanal
Parallellsparad
Nej
Övriga uppgifter
Vetenskapsområden
Växtbiologi, mikrobiologi, virologi
Nyckelord
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Publiceringsland
Finland
Förlagets internationalitet
Inhemsk
Språk
engelska
Internationell sampublikation
Nej
Sampublikation med ett företag
Nej
Publikationen ingår i undervisnings- och kulturministeriets datainsamling
Ja