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Red Light Optogenetics in Neuroscience

Publiceringsår

2022

Upphovspersoner

Lehtinen, Kimmo; Nokia, Miriam S.; Takala, Heikki

Abstrakt

Optogenetics, a field concentrating on controlling cellular functions by means of light-activated proteins, has shown tremendous potential in neuroscience. It possesses superior spatiotemporal resolution compared to the surgical, electrical, and pharmacological methods traditionally used in studying brain function. A multitude of optogenetic tools for neuroscience have been created that, for example, enable the control of action potential generation via light-activated ion channels. Other optogenetic proteins have been used in the brain, for example, to control long-term potentiation or to ablate specific subtypes of neurons. In in vivo applications, however, the majority of optogenetic tools are operated with blue, green, or yellow light, which all have limited penetration in biological tissues compared to red light and especially infrared light. This difference is significant, especially considering the size of the rodent brain, a major research model in neuroscience. Our review will focus on the utilization of red light-operated optogenetic tools in neuroscience. We first outline the advantages of red light for in vivo studies. Then we provide a brief overview of the red light-activated optogenetic proteins and systems with a focus on new developments in the field. Finally, we will highlight different tools and applications, which further facilitate the use of red light optogenetics in neuroscience.
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Organisationer och upphovspersoner

Jyväskylä universitet

Takala Heikki Orcid -palvelun logo

Lehtinen Kimmo

Nokia Miriam Orcid -palvelun logo

Publikationstyp

Publikationsform

Artikel

Moderpublikationens typ

Tidning

Artikelstyp

En översiktsartikel

Målgrupp

Vetenskaplig

Kollegialt utvärderad

Kollegialt utvärderad

UKM:s publikationstyp

A2 Översiktsartikel i en vetenskaplig tidskrift

Publikationskanalens uppgifter

Volym

15

Artikelnummer

778900

Publikationsforum

70482

Publikationsforumsnivå

1

Öppen tillgång

Öppen tillgänglighet i förläggarens tjänst

Ja

Öppen tillgång till publikationskanalen

Helt öppen publikationskanal

Parallellsparad

Ja

Publiceringsavgift för öppen tillgång €

3302

Betalningsår för den öppen tillgång publiceringsavgiften

2021

Övriga uppgifter

Vetenskapsområden

Biokemi, cell- och molekylärbiologi; Neurovetenskaper

Nyckelord

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Publiceringsland

Schweiz

Förlagets internationalitet

Internationell

Språk

engelska

Internationell sampublikation

Nej

Sampublikation med ett företag

Nej

DOI

10.3389/fncel.2021.778900

Publikationen ingår i undervisnings- och kulturministeriets datainsamling

Ja