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Epigenetic mutations can both help and hinder adaptive evolution

Publiceringsår

2016

Upphovspersoner

Kronholm, Ilkka; Collins, Sinéad

Abstrakt

Epigenetic variation is being integrated into our understanding of adaptation, yet we lack models on how epigenetic mutations affect evolution that includes de novo genetic change. We model the effects of epigenetic mutations on the dynamics and endpoints of adaptive walks—a process where a series of beneficial mutations move a population towards a fitness optimum. We use an individual‐based model of an asexual population, where mutational effects are drawn from Fisher's geometric model. We find cases where epigenetic mutations speed adaptation or result in populations with higher fitness. However, we also find cases where they slow adaptation or result in populations with lower fitness. The effect of epigenetic mutations on adaptive walks depends crucially on their stability and fitness effects relative to genetic mutations, with small‐effect epigenetic mutations generally speeding adaptation, and epigenetic mutations with the same fitness effects as genetic mutations slowing adaptation. Our work reveals a complex relationship between epigenetic mutations and natural selection and highlights the need for empirical data.
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Organisationer och upphovspersoner

Jyväskylä universitet

Kronholm Ilkka Orcid -palvelun logo

Publikationstyp

Publikationsform

Artikel

Moderpublikationens typ

Tidning

Artikelstyp

En originalartikel

Målgrupp

Vetenskaplig

Kollegialt utvärderad

Kollegialt utvärderad

UKM:s publikationstyp

A1 Originalartikel i en vetenskaplig tidskrift

Publikationskanalens uppgifter

Journal/Serie

Molecular Ecology

Volym

25

Nummer

8

Sidor

1856-1868

Publikationsforum

63524

Publikationsforumsnivå

2

Öppen tillgång

Öppen tillgänglighet i förläggarens tjänst

Nej

Parallellsparad

Nej

Övriga uppgifter

Vetenskapsområden

Ekologi, evolutionsbiologi; Genetik, utvecklingsbiologi, fysiologi

Nyckelord

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Publiceringsland

Förenade kungariket

Förlagets internationalitet

Internationell

Språk

engelska

Internationell sampublikation

Ja

Sampublikation med ett företag

Nej

DOI

10.1111/mec.13296

Publikationen ingår i undervisnings- och kulturministeriets datainsamling

Ja