Age is the main risk factor for the prevalent chronic diseases in developed countries. This fact has raised the question whether we should treat aging instead of treating individual diseases. Accumulation of senescent cells with age underlie several chronic diseases, whereas exercise diminishes the markers of cellular senescence. The biological significance of cellular senescence on healthy aging remains yet to be fully understood. Exercise, Extracellular Vesicles and Senescence (EEVaS) study aims to establish the key signaling molecules mediating the senolytic effects of exercise. To reveal the mechanisms, EEVaS study utilizes cell, animal, and human models. The study will be carried out at the Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Finland. When successful, the results of EEVaS study have potential to be translational to human health in delaying the onset of age-related chronic diseases and hence, increasing health span.

2023

2027