CLEANSE-PD

Parkinson's disease is the fastest growing brain disorder worldwide, yet no treatments slow its progression. Many patients suffer from balance, posture, and walking problems that don't respond well to current medications. Recent research suggests that gut bacteria may play a role in Parkinson's. In a previous study, we found that bowel cleansing improved gut health and motor symptoms in some Parkinson's patients. We are now testing whether repeated bowel cleansing can improve walking and balance in patients with abnormal gut bacteria. This randomized, placebo-controlled trial will recruit 82 patients from four hospitals. Half will receive bowel cleansing treatment, and half will receive a placebo solution. We will measure motor symptoms, gut bacteria, and quality of life over 12 months. If successful, this simple, low-cost treatment could provide a new way to improve symptoms and daily function in Parkinson's disease.

2026

2029