Learning and memory involve changes in the synaptic connections between neurons. Neuronal dendritic spines, tiny post-synaptic protrusions, compartmentalize biochemical signals upon receiving synaptic inputs. In this study, we will investigate whether the largest neuronal organelle, the endoplasmic reticulum (ER), contributes to the biochemical compartmentalization of dendritic spines. We will use advanced light and electron microscopy methods to explore ER compartmentalization and study its functional role in synaptic signaling and transmission. Together, this study aims to elucidate novel mechanisms that contribute to synaptic plasticity, a key process underlying learning and memory. As a result, our work can further our understanding of the brain's molecular function and pave the way for treatment strategies for neurological disorders where synaptic function is distorted.

2024

2028