Harmonising and Unifying Blood Metabolomic Analysis Networks
Akronym
HUMAN
Bidragets beskrivning
Metabolomics provides a real-time view of the metabolic state of the examined samples. The past decade the field showed strong growth, however limitations intrinsic to the field hinder further application in epidemiology level. Key obstacles include: variety of analyte molecular structures, slow marker identification, large differences in concentrations, poor validation, incomplete combination of data from different analyses and fragmentation of research. The consortium brings together scientists from different complementary disciplines and sectors to collaborate and set a research training network, combining infrastructure experience, knowledge and skills. The research scope is to identify the source of problems that hinder development, and recommend measures to overcome these. Training through
research will promote a new generation of omics researchers. Networking, joining forces via secondments will enhance research productivity transfer of knowledge. The project will train 10 ESRs in work-packages aiming toward improvement of design of experiment, harmonization of analytical methods, improved Data Mining and biochemical pathway analysis and translational research. Application will be in the study of blood metabolome of exhaustive physical exercise.
We aim to study sample stability & preparation (including blood and alternative forms such as dried blood spots), biomarker identification, exploitation of multiple datasets, promote standard procedures, develop robust pipelines, develop and implement machine searchable notations of metadata, central database for data storage, compare datasets, automate cross-laboratory data combination, develop novel algorithms for multidimensional data mining and reconstruct biochemical pathways. The overall goal is to train the ESRs in cutting edge metabolomics research and at the same time provide proof of concept of democratizing metabolomics by the use of patient centric sampling.
Visa merStartår
2023
Slutår
2027
Beviljade finansiering
Participant
AFEKTA TECHNOLOGIES LTD
286 488 €
Participant
TRAJAN SCIENTIFIC EUROPE LTD (UK)
Participant
Marc Becker (DE)
Participant
Theta Biomarkers (EL)
Participant
Theta Biomarkers (EL)
Participant
THETABIOMARKERS IKE (EL)
Participant
Physikit UG (DE)
Participant
Physikit UG (DE)
Participant
Bright Giant GmbH (DE)
Participant
Violeitourgiki IKE (IMON International) (EL)
Participant
Violeitourgiki IKE (IMON International) (EL)
Participant
BRUKER DALTONICS GMBH & CO KG (DE)
Participant
CAPITAINER AB (SE)
Participant
ANALYSI (EL)
Participant
ANALYSI (EL)
Participant
FASMATECH EPISTIMONIKI KAI TECHNOLOGIKI ANONYMI ETAIREIA (EL)
Participant
FUNDACION UNIVERSITARIA SAN PABLO-CEU (ES)
251 971.2 €
Participant
UNIVERSITE PAUL SABATIER TOULOUSE III (FR)
Participant
FRIEDRICH-SCHILLER-UNIVERSITAT JENA (DE)
260 539.2 €
Participant
ACCADEMIA EUROPEA DI BOLZANO (IT)
259 437.6 €
Participant
ARISTOTELIO PANEPISTIMIO THESSALONIKIS (EL)
720 295.2 €
Coordinator
TECHNISCHE UNIVERSITAET MUENCHEN (DE)
Participant
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (FR)
282 693.6 €
Participant
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE (UK)
Participant
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH (DE)
521 078.4 €
Participant
Beviljat belopp
2 582 503 €
Finansiär
Europeiska unionen
Typ av finansiering
HORIZON TMA MSCA Doctoral Networks
Ramprogram
Horizon Europe (HORIZON)
Utlysning
Programdel
Marie Skłodowska-Curie Actions (MSCA) (11677Tema
MSCA Doctoral Networks 2021 (HORIZON-MSCA-2021-DN-01-01Utlysnings ID
HORIZON-MSCA-2021-DN-01 Övriga uppgifter
Finansieringsbeslutets nummer
101073062
Identifierade teman
bioinformatics