Positron emission tomography is one of the most commonly utilized non-invasive imaging modalities for diagnosis, staging, and treatment monitoring of cancer, inflammation and neurodegenerative diseases. Currently there is only a limited toolbox of synthetic procedures available for the incorporation of commonly utilized radioisotopes into organic molecules with satisfactory results and reproducibility for clinical imaging solutions. Transition metal-mediated reactions have broadened these capabilities immensely, but the main challenge with these reactions arise from high toxicity of the utilized transition metals, resulting in very strict regulation on elemental traces in pharmaceuticals. Here, the aim is to minimize these risks by depositing the active metal on solid supports in conjunction with selective laser sintering 3D-printing.

2023

2027