The activation of brown fat can be useful for effective weight maintenance. Brown fat metabolism declines with age and it is considered to be a reason for the development of metabolically unhealthy obesity (central obesity) as well as gradual weight gain. We do not clearly understand the reasons for the decline in brown fat metabolism. It is possible that the decline in the availability of the molecule Nicotinamide Adenine Dinucleotide (NAD+), which is central to several metabolic processes, plays a role in the decline in brown fat metabolism. This project aims to investigate the mechanisms that regulate the metabolism of NAD+ in human brown fat and it will also evaluate whether improvement of NAD+ levels can be beneficial for improving brown fat function.

2023

2027