Plasma neurofilament light admission levels and development of axonal pathology in mild traumatic brain injury

Beskrivning

Abstract Background It is known that blood levels of neurofilament light (NF-L) and diffusion-weighted magnetic resonance imaging (DW-MRI) are both associated with outcome of patients with mild traumatic brain injury (mTBI). Here, we sought to examine the association between admission levels of plasma NF-L and white matter (WM) integrity in post-acute stage DW-MRI in patients with mTBI. Methods Ninety-three patients with mTBI (GCS ≥ 13), blood sample for NF-L within 24 h of admission, and DW-MRI ≥ 90 days post-injury (median = 229) were included. Mean fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated from the skeletonized WM tracts of the whole brain. Outcome was assessed using the Extended Glasgow Outcome Scale (GOSE) at the time of imaging. Patients were divided into CT-positive and -negative, and complete (GOSE = 8) and incomplete recovery (GOSE < 8) groups. Results The levels of NF-L and FA correlated negatively in the whole cohort (p = 0.002), in CT-positive patients (p = 0.016), and in those with incomplete recovery (p = 0.005). The same groups showed a positive correlation with mean MD, AD, and RD (p < 0.001—p = 0.011). In CT-negative patients or in patients with full recovery, significant correlations were not found. Conclusion In patients with mTBI, the significant correlation between NF-L levels at admission and diffusion tensor imaging (DTI) measurements of diffuse axonal injury (DAI) over more than 3 months suggests that the early levels of plasma NF-L may associate with the presence of DAI at a later phase of TBI.
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Publiceringsår

2023

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Upphovspersoner

Department of Neuroscience and Biomedical Engineering

David K. Menon - Upphovsperson

Henna-Riikka Maanpää - Upphovsperson

Henrik Zetterberg - Upphovsperson

Iftakher Hossain - Upphovsperson

Jussi Hirvonen - Upphovsperson

Jussi P. Posti - Upphovsperson

Jussi Tallus - Upphovsperson

Kaj Blennow - Upphovsperson

Mark van Gils - Upphovsperson

Mehrbod Mohammadian - Upphovsperson

Olli Tenovuo - Upphovsperson

Peter Hutchinson - Upphovsperson

Riikka S. K. Takala - Upphovsperson

Timo Kurki - Upphovsperson

Timo Roine Orcid -palvelun logo - Upphovsperson

Virginia F. Newcombe - Upphovsperson

Tampere University - Medarbetare

Turku University Hospital - Medarbetare

University of Cambridge - Medarbetare

University of Turku - Medarbetare

figshare - Utgivare

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Neurovetenskaper

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Creative Commons Attribution 4.0 International (CC BY 4.0)

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