Supplementary Material for: Association of Torquetenovirus viremia with physical frailty and cognitive impairment in three independent European cohorts

Beskrivning

Introduction: Immunosenescence and inflammaging have been implicated in the pathophysiology of frailty. Torquetenovirus (TTV), a single-stranded DNA anellovirus, the major component of the human blood virome, shows an increased replication rate with advancing age. An elevated TTV viremia has been associated with an impaired immune function and an increased risk of mortality in the older population. The objective of this study was to analyze the relation between TTV viremia, physical frailty and cognitive impairment Methods: TTV viremia was measured in 1131 nonfrail, 45 physically frail, and 113 cognitively impaired older adults recruited in the MARK-AGE study (overall mean age 64.7±5.9 years), then the results were checked in two other independent cohorts from Spain and Portugal, including 126 frail, 252 prefrail and 141 nonfrail individuals (overall mean age: 77.5±8.3 years). Results: TTV viremia ≥4log was associated with physical frailty (OR: 4.69; 95% CI: 2.06-10.67, p

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Publiceringsår

2023

Typ av data

Upphovspersoner

Tammerfors universitet

Antti Hervonen - Upphovsperson

Mikko Hurme - Upphovsperson

Unknown organization

Alexander Bürkle - Medarbetare

Ana Maseda - Medarbetare

Armanda Teixeira-Gomes - Medarbetare

Birgit Weinberger - Medarbetare

Blanca Laffon - Medarbetare

Christiane Schön - Medarbetare

Claudio Franceschi - Medarbetare

Eduardo Pásaro - Medarbetare

Efstathios S. Gonos - Medarbetare

Eugène Jansen - Medarbetare

Ewa Sikora - Medarbetare

Fabrizio Maggi - Medarbetare

Florence Debacq-Chainiaux - Medarbetare

Francesco Piacenza - Medarbetare

Joao Paulo Teixeira - Medarbetare

José Carlos Millán-Calenti - Medarbetare

Jürgen Bernhardt - Medarbetare

Laura Lorenzo-López - Medarbetare

Lisa MacEra - Medarbetare

M. Liset Rietman - Medarbetare

Marco Malavolta - Medarbetare

Martijn E.T. Dollé - Medarbetare

María Moreno-Villanueva - Medarbetare

Mauro Provinciali - Medarbetare

Miriam Capri - Medarbetare

Nicolle Breusing - Medarbetare

Olivier Toussaint - Medarbetare

P. Eline Slagboom - Medarbetare

Pietro Giorgio Spezia - Medarbetare

Robertina Giacconi - Medarbetare

Solange Costa - Medarbetare

Stefano Bonassi - Medarbetare

Tilman Grune - Medarbetare

Vanessa Valdiglesias - Medarbetare

Wolfgang Stuetz - Medarbetare

figshare - Utgivare

Projekt

Övriga uppgifter

Vetenskapsområden

Allmänmedicin, inre medicin och annan klinisk medicin

Språk

engelska

Öppen tillgång

Öppet

Licens

Creative Commons Attribution 4.0 International (CC BY 4.0)

Nyckelord

Internal medicine

Ämnesord

Temporal täckning

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