Interplay of synaptic changes, neuroinflammation and beta-amyloid in cognitively normal subjects with varying risk of late-onset Alzheimer’s disease (ASIC-E4) – Metadata
Beskrivning
This dataset contains imaging and biomarker measures from cognitively unimpaired volunteers with varying risk for AD due to different APOE genotypes (N=63). The dataset includes the following measurements:
- Brain PET imaging using 11C-PiB (targeting beta-amyloid), 11C-PK11195 (targeting 18 kDa translocator protein) and 11C-UCB-J (targeting SV2a).
- Structural and functional brain magnetic resonance imaging
- Blood biomarker measurements (Abeta, tau, p-tau, NTA-tau, GFAP, NfL)
- Neuropsychological testing
- Laboratory measurements
Study protocol and baseline characteristics have been published and are openly available (Snellman A et al., Front Neurol. 2022 Feb 9;13:826423. doi: 10.3389/fneur.2022.826423. eCollection 2022.)
Visa merPubliceringsår
2023
Typ av data
Upphovspersoner
Turku PET Centre
Juha Rinne - Upphovsperson
Anniina Snellman 
Åbo universitetscentralsjukhus specialupptagningsområde - Rättighetsinnehavare
Projekt
Övriga uppgifter
Vetenskapsområden
Biomedicinska vetenskaper; Neurovetenskaper
Språk
engelska, finska
Öppen tillgång
Öppet