This research investigates how unique aspects of space environments, particularly microgravity, influence the human body. Previous studies have shown that microgravity affects cellular membranes and immune responses; however, its impact on the respiratory tract cells remains poorly understood. Using advanced respiratory cell models and a microgravity simulator, this study will assess whether microgravity alters epithelial integrity, cell–cell communication, and immune function. The models will be exposed to inhalable particulate materials, including lunar and Martian dust simulants, to evaluate combined effects. A range of toxicological, membrane integrity, and multi-omics assays will be applied to identify potential adverse outcomes. By integrating inhalation toxicology, space toxicology, and environmental health, this research aims to support the development of protective strategies that enhance human health and safety in future extraterrestrial environments.

2026

2030