Atherosclerosis is a chronic inflammatory disease characterized by lipid-deposits, or plaques, on arterial walls. These plaques can prevent blood flow, and upon rupture lead to myocardial or cerebral infarction. Cardiovascular diseases (CVDs) cause 20 million deaths annually, representing a major global health problem. While elevated blood pressure and cholesterol are established risk factors, infections and oral bacteria have also been associated with increased infarction risk. However, the role of oral bacteria in cardiovascular pathology remains poorly understood. This study employs a mouse model of advanced atherosclerosis to investigate the translocation of oral bacteria into arteries, their impact on infarction risk, and the potential for vaccination-based prevention. Our research is important for advancing the understanding of the role of oral bacteria as a risk factor for CVD. The findings may also facilitate the development of new therapeutic strategies against the disease.

2026

2030