This project will clarify metabolic mechanisms of dilated cardiomyopathy (DCM). DCM is the most common form of cardiomyopathy, the third most common cause of heart failure and the most common cause for cardiac transplantation and sudden death in young adults. The estimated annual prevalence of DCM is 1/400-2500, the increase attributed to improved diagnostic methods and Covid19 epidemic-related DCM. A high unmet need exists for mechanistic knowledge and therapy for DCM. We will combine our deep expertise in mitochondrial and metabolic mechanisms with clinical questions and data to versatile tool set of models and state-of-the-art methods to clarify the mechanism why viruses and alcohol predispose to DCM. The impact of the research for rare and DCM forms is high, with the aim to develop novel means for diagnosis and interventions.

2026

2031