Animal tissues are constantly renewed, which is enabled by stem cells. Tissue renewal is carefully regulated and disturbances in this process may lead to declining organ function. Tissues are spatially organized, for example in the intestine nutrient intake and metabolic reactions occur in specific areas. It is still unclear how the tissue's functional regionality affects tissue renewal. Here we will investigate the region-specific regulation of intestinal turnover and its dependence on nutrition. Our goal is to understand at the molecular level how communication between intestinal cells controls regional renewal and what is its physiological role during aging.

2025

2029