The destruction of myelin, the insulating material that surrounds the axons of neurons, is normally followed by an efficient process of repair (remyelination). However, remyelination fails in multiple sclerosis (MS) patients. Why? Interestingly, non-remyelinating MS lesions display perivascular cells (PVCs) abnormalities. Our studies place PVCs as promoters of myelin repair, however, other studies also positioned PVCs as drivers for fibrotic scar formation. Are these cells a friend or a foe? Do PVCs help to produce new myelin or, at the contrary, do they form scar tissue and hamper regeneration? Using cutting-edge techniques, this project pretends to reveal the origin, identity and function of these cells. Unveiling these challenging questions will pave the way for the development of regenerative therapies for MS.

2025

2029