The EVOLVE project investigates how microbiota-derived extracellular vesicles (bEVs), influence maternal and fetal health during pregnancy and early childhood development. These vesicles act as messengers, carrying proteins, genetic material, and metabolites that can affect immune responses, gut development, and overall health. Our research focuses on understanding how bEVs from maternal microbiota (gut bacteria) communicate with the developing fetus, shaping immune programming and gut maturation. We are particularly interested in how factors like antibiotics, changes in gut bacteria, and delivery mode impact this communication. Using state-of-the-art techniques, including multi-omics approaches, and In-vivo models, we aim to discover the role of bEVs and its molecular mechanisms in immune development in children. The EVOLVE project also emphasizes open science, ensuring that data generated during the study is shared through public databases.

2025

2029