Bioengineered ß-glucan for cardiac pre-conditioning: Molecular mechanism and pharmaceutical approaches thereof
Bidragets beskrivning
Cardiovascular diseases (CVDs) represent major healthcare burdens for Finnish people. Instead of focusing on treatment after heart attacks occur, this project aims alternative ways. This project aims to bioengineer a natural substance, ß-glucan (derived from barley), into an oral formulation, and this can “train” our body to better resist heart damage. This may generate a simple, affordable mini-capsules that can be taken daily, so no injections or complex procedures needed. I will produce the engineered ß-glucan formulations using a method named microfluidics, which has been used by creating COVID-19 vaccines, and conduct laboratory studies to see how they affect heart cells under stress. By understanding the biological mechanisms behind this protective effect, I hope to discover a new, preventive strategy against CVDs. Hopefully, this finding could lower healthcare costs, improve patient quality of life, and open new directions in cardiovascular prevention.
Visa merStartår
2025
Slutår
2029
Beviljade finansiering
Finansiär
Finlands Akademi
Typ av finansiering
Akademiforskare
Beslutfattare
Forskningsrådet för biovetenskap, hälsa och miljö
16.06.2025
16.06.2025
Övriga uppgifter
Finansieringsbeslutets nummer
370362
Vetenskapsområden
Farmaci
Forskningsområden
Farmasia
Identifierade teman
diabetes, medicine, metabolic diseases