Bioengineered ß-glucan for cardiac pre-conditioning: Molecular mechanism and pharmaceutical approaches thereof

Bidragets beskrivning

Cardiovascular diseases (CVDs) represent major healthcare burdens for Finnish people. Instead of focusing on treatment after heart attacks occur, this project aims alternative ways. This project aims to bioengineer a natural substance, ß-glucan (derived from barley), into an oral formulation, and this can “train” our body to better resist heart damage. This may generate a simple, affordable mini-capsules that can be taken daily, so no injections or complex procedures needed. I will produce the engineered ß-glucan formulations using a method named microfluidics, which has been used by creating COVID-19 vaccines, and conduct laboratory studies to see how they affect heart cells under stress. By understanding the biological mechanisms behind this protective effect, I hope to discover a new, preventive strategy against CVDs. Hopefully, this finding could lower healthcare costs, improve patient quality of life, and open new directions in cardiovascular prevention.
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Startår

2025

Slutår

2029

Beviljade finansiering

Zehua Liu Orcid -palvelun logo
670 104 €

Finansiär

Finlands Akademi

Typ av finansiering

Akademiforskare

Beslutfattare

Forskningsrådet för biovetenskap, hälsa och miljö
16.06.2025

Övriga uppgifter

Finansieringsbeslutets nummer

370362

Vetenskapsområden

Farmaci

Forskningsområden

Farmasia

Identifierade teman

diabetes, medicine, metabolic diseases