This research investigates how genetic and environmental stress contribute to synaptic dysfunction in schizophrenia. We examine a new risk variant in the CSMD1 gene, which is highly expressed in the brain and linked to environmental risks through stress and immune system. We use CRISPR gene editing to introduce this risk variant into human stem cells, which are then differentiated into brain cells. In addition, we expose the brain cell cultures to stress hormones and measure the effects on cell function and structure. The research is performed by Dr. Henna Jäntti at the University of Eastern Finland, A.I. Virtanen Institute, as part of international collaboration. The findings will provide new insights into the mechanisms that may explain why some individuals carrying the risk gene remain healthy, while others develop schizophrenia. This research will broaden our understanding of the mechanisms underlying psychiatric disorders and open new avenues for the development of new treatments.

2025

2029