A dynamic view of protein complexes: A new approach for the treatment of neurodegenerative diseases
Bidragets beskrivning
This project examines protein complexes that are associated to neurodegenerative diseases using high performance computing. The aim is to explore the dynamic changes in complexes due to the inhibitors or stimulators of various proteins. The protein regulators can have major impact on protein dynamics which also effects on the protein complex. This study focus on protein phosphatase 2 (PP2A) and its regulator proteins, Prolyl oligopeptidase (PREP) and Midline1 (MID1). We will study the protein complexes by applying the protein-protein docking tools and the stability and dynamics of complexes with molecular dynamics.
Visa merStartår
2025
Slutår
2027
Beviljade finansiering
Finansiär
Finlands Akademi
Typ av finansiering
Akademiprojekt med särskild inriktning
Utlysning
Beslutfattare
Suomen akatemian muu päättäjä
18.12.2024
18.12.2024
Övriga uppgifter
Finansieringsbeslutets nummer
364622
Vetenskapsområden
Kemi
Forskningsområden
Orgaaninen kemia