A dynamic view of protein complexes: A new approach for the treatment of neurodegenerative diseases

Bidragets beskrivning

This project examines protein complexes that are associated to neurodegenerative diseases using high performance computing. The aim is to explore the dynamic changes in complexes due to the inhibitors or stimulators of various proteins. The protein regulators can have major impact on protein dynamics which also effects on the protein complex. This study focus on protein phosphatase 2 (PP2A) and its regulator proteins, Prolyl oligopeptidase (PREP) and Midline1 (MID1). We will study the protein complexes by applying the protein-protein docking tools and the stability and dynamics of complexes with molecular dynamics.
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Startår

2025

Slutår

2027

Beviljade finansiering

Maija Lahtela-Kakkonen Orcid -palvelun logo
442 819 €

Finansiär

Finlands Akademi

Typ av finansiering

Akademiprojekt med särskild inriktning

Beslutfattare

Suomen akatemian muu päättäjä
18.12.2024

Övriga uppgifter

Finansieringsbeslutets nummer

364622

Vetenskapsområden

Kemi

Forskningsområden

Orgaaninen kemia