Enhancing NMR sensitivity through metal-free catalysis

Bidragets beskrivning

NMR spectroscopy and MRI provide unique possibilities for the elucidation of molecular structures and dynamics in chemistry, biology, and medicine. At the same time, they are considered insensitive methods due to intrinsically low spin polarization under normal conditions. This can be dramatically improved by developing front-line spin hyperpolarization techniques such as parahydrogen-induced polarization (PHIP), which is affordable as compared to other techniques. However, it is based on the activation of parahydrogen by toxic metal catalysts. In this project, we develop NMR methodologies based on the use of metal-free catalysts in PHIP. We perform in-depth joint computational-experimental research to find the best metal-free catalysts and tune the most important spin-spin interactions to achieve strong hyperpolarization. This is then used in important biomolecular and materials science applications.
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Startår

2024

Slutår

2028

Beviljade finansiering

Vladimir Zhivonitko Orcid -palvelun logo
599 904 €

Finansiär

Finlands Akademi

Typ av finansiering

Akademiprojekt

Beslutfattare

Forskningsrådet för naturvetenskap och teknik
13.06.2024

Övriga uppgifter

Finansieringsbeslutets nummer

362959

Vetenskapsområden

Kemi

Forskningsområden

Fysikaalinen kemia