Dementia is a complex multifactorial condition. Effective prevention thus likely requires combining interventions (multimodal approach) early in the disease process to address multiple disease mechanisms and risk factors simultaneously. Multi-MeMo aligns experimental molecular, cellular, and animal models with a strong array of unique multimodal human trials with shown multi-year cognitive and functional benefits. This will allow in-depth analysis of multiple molecular and cellular mechanisms that cannot be clarified from human trials alone, as well as rapid validation of identified mechanisms for clinical relevance with successful long-term (up to 11 years) human trial data and samples. We also aim to develop an enhanced multimodal intervention model, compatible for combinations of pharmacological and non-pharmacological modalities that enhance each other's effects. Project results will ultimately lead to timely, personalised interventions to effectively prevent/delay dementia onset.

2023

2026