Energy in the form of ATP is produced in the mitochondria of the cell by a complex interplay of charged particles. Despite decades of research efforts, it is not fully understood how it is accomplished, and how diseases are related to malfunction in this process. In this project, we will study one of the most complicated proteins, mitochondrial respiratory complex I, which is central to ATP production. By applying computer modeling and simulations on high-performance supercomputers, we will learn how complex I functions, and how its function breaks down due to disease-causing mutations. Our work will enhance understanding of one of the most fundamental processes in biology that is energy production.

2021

2025