Impact of cell size in regulating stem cell function during aging and disease

Bidragets beskrivning

The increasing number of elderly affected by age-related blood dysfunction and malignancies is one of the most significant public health challenges today. A major contributor to this age-related decay is the loss of blood stem cell function. Nevertheless, we know little of how blood stem cells become dysfunctional with age. Our previous work demonstrates that blood cell size is a key determinant of stem cell function and that enlargement of blood stem cells contributes to their fitness decline during aging. This project is anticipated to reveal how blood stem cells lose their fitness upon enlargement during aging and whether this increase in their size facilitates cancerous transformation. It is essential to further our understanding of the role of stem cells in aging and cancer to offer new therapeutic implications for rejuvenation therapies that improve stem cells function and thereby preserve the health of an aging or cancerous blood system.
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Startår

2021

Slutår

2026

Beviljade finansiering

Jette Lengefeld Orcid -palvelun logo
447 650 €

Andra beslut

361973
Akademiforskarens forskningskostnader(2024)
200 000 €
346347
Akademiforskarens forskningskostnader(2021)
300 000 €

Finansiär

Finlands Akademi

Typ av finansiering

Akademiforskare

Övriga uppgifter

Finansieringsbeslutets nummer

340601

Vetenskapsområden

Biokemi, cell- och molekylärbiologi

Forskningsområden

Solu- ja molekyylibiologia

Identifierade teman

other