Oxygen-18 and carbon-13 isotopes in eCO(2) and erythrocytes carbonic anhydrase activity of Finnish prediabetic population
Publiceringsår
2021
Upphovspersoner
Kårlund, Anna; Kääriäinen, Teemu; Kostamo, Vili M.; Kokkola, Tarja; Kolehmainen, Marjukka; Lakka, Timo A.; Pihlajamäki, Jussi; Manninen, Albert
Abstrakt
<p>Complex human physiological processes create the stable isotopic composition of exhaled carbon dioxide (eCO <sub>2</sub>), measurable with noninvasive breath tests. Recently, isotope-selective breath tests utilizing natural fluctuation in <sup>18</sup>O/ <sup>16</sup>O isotope ratio in eCO <sub>2</sub> have been proposed for screening prediabetic (PD) individuals. It has been suggested that <sup>18</sup>O/ <sup>16</sup>O fractionation patterns reflect shifts in the activity of carbonic anhydrase (CA), an enzyme involved in the metabolic changes in the PD state. To evaluate the applicability of the breath sampling method in Finnish PD individuals, breath delta values (BDVs, %) of <sup>18</sup>O/ <sup>16</sup>O (δ <sup>18</sup>O) were monitored for 120 min in real-time with a high-precision optical isotope ratio spectrometer, both in the fasting state and during a 2 h oral glucose tolerance test (2 h OGTT) with non-labeled glucose. In addition, the BDV of <sup>13</sup>C/ <sup>12</sup>C (δ <sup>13</sup>C) was measured, and total erythrocyte CA activity was determined. δ <sup>18</sup>O and CA did not demonstrate any statistically significant differences between PD and non-diabetic control (NDC) participants. Instead, δ <sup>13</sup>C was significantly lower in PD patients in comparison to NDCs in the fasting state and at time points 90 and 120 min of the 2 h OGTT, thus indicating slightly better potential in identifying Finnish PD individuals. However, overlapping values were measured in PD participants and NDCs, and therefore, δ <sup>13</sup>C cannot be applied as a sole measure in screening prediabetes at an individual level. Thus, because the combination of environmental and lifestyle factors and anthropometric parameters has a greater effect on glucose metabolism and CA activity in comparison to the PD state, <sup>18</sup>O/ <sup>16</sup>O and <sup>13</sup>C/ <sup>12</sup>C fractionations or CA activity did not prove to be reliable biomarkers for impaired glucose tolerance in Finnish subjects. This study was conducted under the clinicaltrials.gov ID NCT03156478. </p>
Visa merOrganisationer och upphovspersoner
Helsingfors universitet
Kostamo Vili M.
Östra Finlands universitet
Lakka Timo
Kokkola Tarja
Kårlund Anna
Pihlajamäki Jussi
Kolehmainen Marjukka
Publikationstyp
Publikationsform
Artikel
Moderpublikationens typ
Tidning
Artikelstyp
En originalartikel
Målgrupp
VetenskapligKollegialt utvärderad
Kollegialt utvärderadUKM:s publikationstyp
A1 Originalartikel i en vetenskaplig tidskriftPublikationskanalens uppgifter
Journal
Moderpublikationens namn
Volym
15
Nummer
2
Artikelnummer
021001
ISSN
Publikationsforum
Publikationsforumsnivå
1
Öppen tillgång
Öppen tillgänglighet i förläggarens tjänst
Ja
Öppen tillgång till publikationskanalen
Delvis öppen publikationskanal
Licens för förläggarens version
CC BY
Parallellsparad
Ja
Parallellagringens licens
CC BY
Publiceringsavgift för öppen tillgång €
2315
Betalningsår för den öppen tillgång publiceringsavgiften
2021
Övriga uppgifter
Vetenskapsområden
Biokemi, cell- och molekylärbiologi; Biomedicinska vetenskaper; Allmänmedicin, inre medicin och annan klinisk medicin; Hälsovetenskap
Nyckelord
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Förlagets internationalitet
Internationell
Språk
engelska
Internationell sampublikation
Nej
Sampublikation med ett företag
Nej
DOI
10.1088/1752-7163/abd28d
Publikationen ingår i undervisnings- och kulturministeriets datainsamling
Ja