Anodal tDCS Over the Left Prefrontal Cortex Does Not Cause Clinically Significant Changes in Circulating Metabolites
Publiceringsår
2020
Upphovspersoner
Kortteenniemi, Aaron M.; Ortega-Alonso, Alfredo; Javadi, Amir-Homayoun; Tolmunen, Tommi; Ali-Sisto, Toni; Kotilainen, Tuukka; Wikgren, Jan; Karhunen, Leila; Velagapudi, Vidya; Lehto, Soili M.
Abstrakt
Background: Transcranial direct current stimulation (tDCS), a putative treatment for depression, has been proposed to affect peripheral metabolism. Metabolic products from brain tissue may also cross the blood-brain-barrier, reflecting the conditions in the brain. However, there are no previous data regarding the effect of tDCS on circulating metabolites. Objective: To determine if 5 daily sessions of tDCS modulate peripheral metabolites in healthy adult men. Methods: This double-blind, randomized controlled trial involved 79 healthy males (aged 20–40 years) divided into two groups, one receiving tDCS (2 mA), the other being sham stimulated. The anode was placed over the left dorsolateral prefrontal cortex, and the cathode over the corresponding contralateral area. Venous blood samples were obtained before and after the first stimulation session, and after the fifth stimulation session. Serum levels of 102 metabolites were determined by mass spectrometry. The results were analysed with generalised estimating equations corrected for family-wise error rate. In addition, we performed power calculations estimating sample sizes necessary for future research. Results: TDCS-related variation in serum metabolite levels was extremely small and statistically non-significant. Power calculations indicated that for the observed variation to be deemed significant, samples sizes of up to 11000 subjects per group would be required, depending on the metabolite of interest. Conclusion: Our study found that 5 sessions of tDCS induced no major effects on peripheral metabolites among healthy men. These observations support the view of tDCS is a safe treatment, and do not support the previously suggested modulatory impact on peripheral metabolic processes.
Visa merOrganisationer och upphovspersoner
Institutet för hälsa och välfärd
Ortega-Alonso Alfredo
Helsingforsregionens universitetscentralsjukhus specialupptagningsområde
Ortega-Alonso Alfredo
Lehto Soili M.
Velagapudi Vidya
Publikationstyp
Publikationsform
Artikel
Moderpublikationens typ
Tidning
Artikelstyp
En originalartikel
Målgrupp
VetenskapligKollegialt utvärderad
Kollegialt utvärderadUKM:s publikationstyp
A1 Originalartikel i en vetenskaplig tidskriftPublikationskanalens uppgifter
Journal
Moderpublikationens namn
Volym
11
Artikelnummer
403
ISSN
Publikationsforum
Publikationsforumsnivå
1
Öppen tillgång
Öppen tillgänglighet i förläggarens tjänst
Ja
Öppen tillgång till publikationskanalen
Helt öppen publikationskanal
Parallellsparad
Ja
Parallellagringens licens
CC BY
Övriga uppgifter
Vetenskapsområden
Neurovetenskaper; Neurologi och psykiatri; Psykologi
Nyckelord
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Publiceringsland
Schweiz
Förlagets internationalitet
Internationell
Språk
engelska
Internationell sampublikation
Ja
Sampublikation med ett företag
Nej
DOI
10.3389/fpsyt.2020.00403
Publikationen ingår i undervisnings- och kulturministeriets datainsamling
Ja